Mission: To contribute to the discovery of new molecular targets for chemotherapy of Chagas disease and Leishmaniasis, drug resistance mechanisms and molecular aspects of host-parasite interaction using functional analysis and glycobiology of Leishmania spp. and Trypanosoma cruzi.
Principal Investigators: Silvane Maria Fonseca Murta and Rodrigo Pedro Pinto Soares
Diseases: Chagas disease and Leishmaniasis
Research lines:
- Identification of new targets for chemotherapy studies of susceptible and drug-resistant Leishmania spp. and T. cruzi lines using a transcriptomic and genomic approach
- Proteomic and phosphoproteomic analysis of susceptible and drug-resistant Leishmania spp. and T. cruzi lines
- Molecular characterization and functional analysis of the enzymes involved in the antioxidant defense and trypanothione biosynthesis pathway of susceptible and drug-resistant Leishmania spp. and T. cruzi lines
- Transcriptomic analysis of susceptible and drug-resistant Leishmania spp. and T. cruzi lines
- Identification of possible candidates antigens for vaccine against Visceral leishmaniasis using proteomic analysis
- Assays of compounds / extracts with leishmanicide activity
- Search for new drugs with trypanocidal activity using anti-T. cruzi bioassay platform
- Study of genetic diversity of T. cruzi strains isolated from different geographic regions and hosts
- Glycobiology studies in T. cruzi and Leishmania
- Molecular aspects of parasite-host interaction
- Analysis of the LRV-1 virus in L. braziliensis
- Repositioning of drugs used in cancer chemotherapy as an alternative for the treatment of leishmaniasis
- Search for new models for prospection of drugs and study of the mechanisms of action
RESEARCHERS FROM CPqRR:
Alvaro Romanha
Ana Rabelo
Andrea Teixeira
Carlos Zani
Célia Maria Ferreira Gontijo
Guilherme Correa Oliveira
Jerônimo C. Ruiz
Laila Alves Nahum
Policarpo Ademar Sales Junior
Rodrigo Corrêa
Rodrigo Pedro Pinto Soares
Rosiane Aparecida da Silva Pereira
Rubens Lima do Monte Neto
Silvane Maria Fonseca Murta
Tânia Alves
| STUDENTS (UNDERGRADUATE AND GRADUATE)
Bethânia Vaz de Resende |
| Christiana Vargas Ribeiro |
| Diego Henrique Fagundes Macedo |
| Douglas de Souza Moreira |
| Joyce Fernanda Amaro Rodrigues |
| Juvana Moreira Andrade |
| Laila de Carvalho Andrade |
| Mariana Eduarda Aparecida de Souza Assunção Lopes |
| MaÃsa Santos da Fonseca |
| Nayara Junia Areal de Carvalho |
| Paula Monalisa Nogueira |
| Selma da Silva Santos |
TECHNICIANS
| Graziela de Paula Ferreira Dantas |
| Rosana de Oliveira Alves |
RESEARCHERS FROM OTHER BRAZILIAN INSTITUTIONS: Dr. Carlos Renato Machado (UFMG), Dra. Caryne Bertollo (UFMG), Dr. Daniel B. Liarte (UFP), Dr. Edmundo Grisard (UFSC), Dra. Elaine Fagundes (UFMG), Dr. Elmo Eduardo Amaral (FIOCRUZ), Dr. Frederick Frezard (UFMG), Dr. Julio Borges (USP), Dra. Luciana Andrade (UFMG), Dr. Marco Krieger (ICC/FIOCRUZ), Dr. Mario Steindel (UFSC), Dra. Renata Guerra de Sá Cota (UFOP), Dr. Samuel Goldenberg (ICC/FIOCRUZ), Dra. Santuza M.R. Teixeira (UFMG).
FOREIGN RESEARCHERS: Dr. Carlos Robello (Universidade de Montevideo – Uruguai), Dr. Gerald Spaeth (Instituto Pasteur – França), Dr. Jacqueline Bua (Instituto Nacional de Parasitologia, Buenos Aires, Argentina), Dra. LuÃsa Custódio (Universidade do Algarve, Portugal), Dra. LuÃsa Paula Viola Afonso Barreira (Universidade do Algarve, Portugal), Dr. Marc Ouellete (Université Laval, Québec, QC, Canada), Dr. Phillipe Nirde (INSERM – França), Dr. Stephen Beverley (Washington University de Saint Louis/USA).