Cellular and Molecular Immunology

Leaders: Rodrigo Corrêa de Oliveira and Jaquelline Germano de Oliveira

 

Mission:

Study Immunology, Microbiology and Parasitology, including research studies involving parasites and chronic-degenerative diseases, immuno-epidemiology, developing products like vaccines, drugs and methodology for diagnostics and disease prevention.

Action:

Research areas of cellular and molecular immunology of chronic-degenerative diseases and the ones caused by different types of parasites or infectious agents. We also work in epidemiologic and population genetics studies of the diseases above mentioned. Our research aim to develop vaccine targets, drugs and diagnostic methodology to improve disease treatment and investigate the mechanisms under the pathogen-host interaction.

• Main research areas:
  1. Dengue:

• Level of RNAm expression in genes related to innate immune response in peripheral blood cells and dendritic cells from patients with different dengue symptoms – Coordinator: Dr. Carlos Eduardo
• Gene validation used as predicted molecular markers for heamorragic dengue prognostics using real time PCR – Coordenador: Dr. Carlos Eduardo
• Chimeric peptides applied to tetravalent vaccine development to dengue virus disease– Coordinator: Dr. Carlos Eduardo
• Biomarkers identification for severe dengue prognostics– Coordinator: Dr. Carlos Eduardo
• Clinic aspects and prognostics relations of dengue and lipid transporters in human– Coordinator: Dr. Carlos Eduardo
• Antiviral activity evaluation of vegetal extract and fungi from Brazilian biodiversity against dengue virus – Coordinator: Dr. Jaquelline Germano
• Molecular epidemiology of dengue virus infection in Brazil– Coordinator: Dr. Jaquelline Germano

2. Other virus:

• Alterations of gene expression involved with innate immune response in human induced by Orthobunyavirus – Coordinator: Dr. Carlos Eduardo
• Experimental immune response in mice infected with group C Orthobunyavirus – Coordinator: Dr. Jaquelline Germano
• Biomarkers for diagnosis and prognostics of cervical cancer associated to papiloma virus infection in human – Coordinator: Dr. Jaquelline Germano
• Experimental model identification for carcinogenesis caused by papilomavirus – Coordinator: Dr. Jaquelline Germano

1. Schistosomiasis:
   • Immunomics study of Schistosoma mansoni infection resistant cohort induced by praziquantel treatment using protein microarray– Coordinator: Dr. Rodrigo Corrêa, Vice-Coordinator: Dr. Carlos Eduardo
   • Chimeric peptides applied to diagnosis development of ectopic schistosomiasis– Coordinator: Dr. Carlos Eduardo
   • Mathematic model for infection and transmition of schistosomiasis – Coordinator: Dr. Andréa Gazzinelli – Vice-Coordinator: Dr. Rodrigo Correa Oliveira
2. Leishmaniais:
   • Use of attenuated strain of Leishmania donovani (LdCen-/-MIF-/-) as vaccine against visceral leishmaniasis – Coordenator: Dra. Jacqueline Fiúza
   • Influence of HIV protease inhibitor (lopinavir/ritonavir and atazanavir) during experimental mice Leishmania (L.) amazonensis infection – Coordenator: Dr. Érica Alves
   • Influence of HIV protease inhibitor during early stages of experimental mice Leishmania (L.) amazonensis infection – Coordenator: Dr. Érica Alves
3. Chagas´disease:
   • Immunoregulation of Chagas´disease and chronic experimental infection – Coordinator: Dr. Ester Roffe
   • Inflammatory mediators role in the fibrosis and chronic vasculite generation during human and experimental T. cruzi infection – Coordinator: Dr. Ester Roffe
4. Stem cells:
   • Mesenchimal stem cell biology and interaction with immune system in a inflammatory environment – Coordinator: Dr. Adriana Bozzi
5. Skin:
   • Human keratinocytes cultures over suine periocadiac for substitutive culture skin – Coordinator: Dr. Roberta Prado
6. Diabetes
   • Diabetes mellitus type 1 ammelioration in mice treated with hookworm antigen from Necator americanus – Coordinator: Dr. Soraya T Gaze Jangola
   • Progression of diabetes type 1 in susceptible mice treated with vegetal extracts – – Coordinator: Dr. Soraya T Gaze Jangola

Human Resources:

Researchers

Adriana Bozzi de Melo

Jacqueline Araújo Fiúza

Jaquelline Germano de Oliveira

Kelly Alves Bicalho

Marcelo Antonio Pascoal Xavier

Ana Thereza Chaves

Maria Victoria Periago

Carlos Eduardo Calzavara Silva

Roberta Oliveira Prado

Érica Alessandra Rocha Alves

Rodrigo Correa de Oliveira

Ester Roffê Santiago

Soraya Torres Gaze Jangola

Leonardo Ferreira Matoso

Bárbara  Resende Quinan

Maria Marta

Alda Maria Silveira Simões

Alexandre Barbosa Reis

Andréa Gazzinelli Corrêa de Oliveira

Andréa Teixeira de Carvalho

Claudia Martins Carneiro

David Diemert

Erna Geessien Kroon

Fernanda Nobre Amaral Villani

Flávio Guimarães da Fonseca

Fernanda Ludolf Ribeirof

Giovanni Gazzinelli

Guilherme Corrêa de Oliveira

Helton da Costa Santiago

Juliana de Assis Silva Gomes Estanislau

Lúcia Alves de Oliveira Fraga

Manoel Otávio da Costa Rocha

Olindo Assis Martins Filho

Paulo César Peregrino Ferreira

Ricardo Toshio Fujiwara

Rodolfo Cordeiro Giunchetti

Stefan Michael Geiger

Students

Anna Carolina Cançado Figueiredo

Jorge Gomes Goulart Ferreira

Bárbara Betônico Berg

Carolina de Souza Gonçalves

Dirli Emerick Eller

Emerson de Castro Barbosa

Isabel Faloh Gandarilla

Roberta ISabelly Rodrigues

Izabella Cristina Andrade Batista

Nayara Ingred de Medeiros – Mestrado

Roberta Isabelly Rodrigues – Apoio Técnico

Vinicius Paz Sampaio – Apoio Técnico

Vitor Hugo Miranda

Nadine Julia Greco

Juliana Bellardini

Lorena Cassia N Ferraz

Luiza Carvalho Dilly DAngelo

Eneida Santos de Oliveira

Guilherme C. Fernandes Silva

Technicians

Ana Maria Pacheco de Araújo

Antonio José Caetano

Cassia Ronise Senra Silva

Clari Lopes Gandra Martins

Fernanda Gambogi de Oliveira

Luciana Lisboa Mota e Castro

Renata Caldeira Diniz

Ricardo Ribeiro de Andrade

Simone Aparecida Pinto

Stella Maris Pereira Sobrinho Rodrigues

Julia Duarte Gandra